Resistance 2 follows Nathan Hale as he finds himself once more in a world transformed by war and invasion. Undaunted by their defeat in London, the Chimera have continued to advance and are now poised to attack the United States. Entire cities have been leveled and communities annihilated. In this war where the odds are so heavily stacked against the human race, few are left who are willing and able to fight. Fortunately, Hale is not alone. A group of super soldiers known as the Sentinels will fight alongside Hale as they collectively attempt to thwart the inevitable.